What is Vitamin C?
Vitamin C is a nutrient supplement and a powerful antioxidant that aids to prevent damage to cells caused by free radicals and also operates with enzymes to play a key role in making collagen. Vitamin C is also known as L-ascorbic acid or ascorbate.
Sources of Vitamin C
It is abundantly found in various food such as oranges, grapefruit, papaya, kiwi, peppers, and kale.
What is High dose Vitamin C?
High dose Vitamin C is a concentrated form of Vitamin C and can be prone by IV infusion or taken orally because of the effective higher blood levels are reached when it is given intravenously.
The clinical experts are researching high dose vitamin C to treat the tumor cells and are used to test a substance to analyze whether it is having any anticancer effects. It was tested on animals before it was used on people, the results showed a positive effect and proved that the treatment is safe and effective. Hence the clinical studies recommend that high dose vitamin C can kill cancer cells. Now recent studies are suggesting high dose vitamin C supplements can be given to treat COVID-19 patients.
Research on High dose vitamin C to treat Coronavirus patients
Many of us know that there is no specific drug invented to treat COVID-19 patients but still clinical research is going on by the expert’s Medicine/Drugs research for COVID-19 (Coronavirus) patients. Despite that, the experts from Shangai followed by National COVID-19 Diagnosis and Treatment program did deep discussion online about the effects of high dose vitamin C on COVID-19 patients. The group of Doctors eminent from different hospitals from different countries across the world. Dr, Enqiang Mao from Shanghai China, Dr, Atsuo Yanagisawa, and Dr, Jun Matsuyama from Tokyo Japan, Dr. Maurice Beer and Asa Kitfield from New York and many more doctors across the world did the brief meeting of 45 minutes to reduce the severity and prevention of COVID-19.
The meeting was all about an infusion of High dose vitamin C during the early stage of COVID-19 in infected patients. This medication is quite helpful, however, the data is yet to be finalized and published later. The patients appeared to have hyper-coagulability and Heparin is used to reduce the severity of coagulation issues. One important thing was a suitable schedule to wear protective attire for intubation and how to overcome other unexpected dangers.
Oral Vitamin C intake helps in reducing the infection caused by the virus and also improves symptoms of cold and flu. The experts conducted a 30 days training program, a category of young and healthy military recruits from Korea over 1444 people. Among them, 695 people received high dose vitamin C and the rest of them didn’t receive it. In earlier research, a group of 463 students between 18 to 32 years of age was divided into two categories. Vitamin C was fed orally to a group of 252 students who reported upper respiratory infection symptoms. They were suggested to consume 1000 mg of high dose vitamin C for 6 hours once and later on 3 times per day. On keen observation, a reduction in symptoms was noted, and the experts concluded that it is decreased to 85% with the help of high dose vitamin C.
According to Kim TK, Lim HR, and Byun, a high dose vitamin C boost reduces the cold symptoms. Gorton HC, Jarvis K opine, a high dose vitamin C prevents the development of respiratory infection signs. High-dose Vitamin C favors reducing the inflammation in extreme respiratory illness that is acute respiratory inflammation caused during viral infection and also boosts the immunity system. It has a special feature to boost the activity of phagocytes, immune cells that burst harmful bacteria and also it motivates the growth and spread of lymphocytes, a kind of immune cell that increases in circulating antibodies, this protein that can fight against harmful foreign bodies. But studies of its effectiveness against viruses that cause the common cold suggest that vitamin C doesn’t appear to make you any less likely to get over from cold, it may help heal the cold faster and make the symptoms less severe.
By observing positive Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) about high dose vitamin C in New York, the medical faculties of Northwell health facilities spontaneously took the decision and gave 1500 milligram of vitamin C intravenously to the affected patients and suggested to take the same amount 3-4 times per day, here also it shows significant change as compared to the patients who are not taken.
Dr. Andrew Weber, a critical care specialist affiliated to Northwell health told that high dose vitamin C administered along with the medicine such as hydroxychloroquine, azithromycin, and other blood thinners. Even it was applied to ICU patients in Australia and hence it shortens the need for mechanical ventilation.
Side effects of high dose vitamin C
All of us know that everything has its pros and cons even it has its drawbacks, and the doctor should be careful, take patient history before prescribing high-dose vitamin C
- The body will not absorb excess vitamin C and will excrete the excess in the form of urine. Some times it may cause diarrhea.
- If the patient has a history of kidney problems, there is a chance to develop kidney stones because of high-dose vitamin C.
- Patients who inherit a disorder called G6PD deficiency should not be administered with the drug. It is a special type of condition in which red blood cells are destroyed, in short, called hemolysis.
- Even high doses of vitamin C are not recommended for patients with hemochromatosis. Hence high dose vitamin C should be consumed under the prescription of doctors.
There is an urgent need to develop an effective vaccine for this highly pandemic respiratory virus, that has spread globally in a short period as an important epidemic control measure. Inactivated whole virus, mRNA, DNA, recombinant protein recombinant adenovirus vaccines are being developed. Clinical studies are already underway for a few of them in animals. Considering the experience of disease enhancement by inactivated whole virus measles vaccine in the past and similar reports in animal studies with SARS coronavirus vaccines, the need of the time is a safe and effective vaccine in the area of coronavirus infection. Doctors, research institutes hope these vaccine candidates rapidly move into appropriate phase-3 clinical trials in humans soon.
In a nutshell, priority research is being focussed on areas of diagnostics, therapeutics, and vaccines. Diagnostics modes include RNA assays, antibody & antigen assays, point of care detection. Drug therapy using redeliver, favipiravir, chloroquine, plasma, TCM alone or in combination is being investigated. Vaccines like mRNA candidates and candidate viral vectors, inactivated and subunit candidates are being researched.